Hypoglycemia, low blood sugar, is a disorder that occurs mainly in small
breed puppies between six and twelve weeks of age.  It is often precipitated
by stress and can occur without warning (if the puppy is susceptible).  It
might appear after the puppy misses a meal, chills, becomes exhausted from
playing, or has a digestive upset.  These upsets place an added strain on
the energy reserves and bring on symptoms.

Hypoglycemia is a real threat to these tiny puppies, watch for your puppy
to become tired or droopy.  The first signs are those of listlessness and
depression.  Muscular weakness, tremors, and later convulsions, coma and even death may follow.  The puppy may appear depressed or may be weak, wobbly and jerky, or the puppy may be found in a coma.

If your puppy has any symptoms of Hypoglycemia you must act fast. If the
puppy is awake, give it Nutrical,  or Karo syrup by mouth. You should
see signs of improvement in thirty minutes. If no improvement call your
veterinarian. If the puppy is unconscious it should be taken to the
veterinarian at once.

Prevent hypoglycemia from happening by allowing only twenty minutes of play at a time, followed by rest or sleep. Do not allow puppy to overtire at first. Supervise closely with children to make sure puppy is getting enough rest. Keep puppy warm, don't let it become chilled. Your puppy is a house dog and should not be living outdoors.

Prevent attacks by feeding a high quality kibble diet. We use and
recommend Proplan puppy food. See that puppy eats at least every 4
hours at first. Keep dry food and water available at all times. You can give ½ teaspoon of Nutrical or Karo syrup morning and night for the first couple of
days to help prevent the low blood sugar that can come with the excitement
and stress of going to a new home.

Smaller puppies can very easily become hypoglycemic.  Watch them carefully, make sure they get enough rest and food.